Causes of Ankylosing spondylitis
Causes of Ankylosing spondylitis (Bechterew's disease), science is still uncertain. However, scientists have brought the relationship between the disease and the presence of a human antigen HLA B27. This does not mean that the presence of the antigen, sooner or later leads to the development of disease, but evidence of a genetic predisposition.
There is a theory according to which the antigen HLA B27 attaches to the similarity of articular tissues carrying the gene of people with certain types of infections. When a gene catches any infection, immune system produces antibodies to fight it. Antibodies destroy the infection, exogenous, and then "attack" the joints, taking them for infection. However, this is one of the hypotheses.
It is known only that the antigen HLA B27 is present in all stricken with Ankylosing spondylitis. But not all carriers of the gene is necessarily ill Ankylosing spondylitis. There is a certain mechanism that starts the program of the disease. This may be an infectious disease, even the common cold, rolled over on his feet. By the development of Ankylosing spondylitis can cause accidental injury or constant stress.
Ironically, the study of Ankylosing spondylitisand its causes in the world, almost no one does. The few studies rarely provide new knowledge about the disease. From recent research we can recall only the experiments on mice, which showed that the disease is similar to Ankylosing spondylitis, these rodents occurs at a combination of three factors: the presence of antigen HLA B27, infection from the outside and the presence of T-lymphocytes in the blood. If the mouse was kept in sterile conditions, either it was removed thymus gland - the body responsible for the production of T-lymphocytes, the disease has developed.
By virtue of the fact that not studied the mechanism of the disease, Ankylosing spondylitis, it is difficult to talk about any prevention. Obviously, people-carrier antigen HLA B27 should closely monitor their health, to avoid traumatic situations in time to treat infectious diseases. People, who already have Ankylosing spondylitis, can only prevent complications and retard the development of spondylitis by continuous therapy, occupation therapy, physical therapy, spa treatment.
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